Assessments of Incorporation of Simvastatin Microparticles in Energy Drink Formulation for Enhancing Anti-oxidant and Anti Inflammatory Activity

The objectives of this current investigation are (1) to develop a multiple-unit microparticulate dosage form for simvastatin (50, 75 and 100 mg drug loads) from a hydrophilic polymer and a positively-charged polysaccharide moiety using a cold dispersion method, (2) to assess the anti-inflammatory and anti-oxidant properties of the energy drink formulation containing drug-loaded microparticles in an in vitro conditions,(3) Formulation of energy drink incorporating antioxidant simvastatin microparticles. Chitin and PEG 6000 were selected respectively as positively-charged polysaccharide moiety and hydrophilic polymer to generate the drug-loaded microparticles. Addition of propylene glycol led the microparticles to form a spherical-shaped matrix. A noteworthy observation came out from this investigation is that simvastatin-loaded microparticles did dissolve completely in the energy drink formulation while the pure drug did not. Even the anti-inflammatory and antioxidant properties of simvastatin were also retained after its incorporation into microparticles as well as its dissolution into the energy drink formulation. This result could give impetus to develop energy drink formulation possessing the re-energizing property along with the antiinflammatory activity.